金纳米粒子/聚多巴胺/碳纳米管修饰玻碳电极对核黄素的测定

doi:10.13208/j.electrochem.150727

电化学（中英文） ›› 2016, Vol. 22 ›› Issue (1): 43-48. doi: 10.13208/j.electrochem.150727

金纳米粒子/聚多巴胺/碳纳米管修饰玻碳电极对核黄素的测定

彭花萍^1,2, 余美玲¹, 刘馨¹, 刘盼^1,2, 陈伟^1,2, 刘爱林^1,2, 林新华^1,2*

1. 福建医科大学药学院药物分析系, 福建福州 350108; 2. 福建省高等学校纳米医药技术重点实验室，福建福州 350108

收稿日期:2015-07-27 修回日期:2015-09-03 出版日期:2016-02-29 发布日期:2015-09-06
通讯作者: 林新华 E-mail:xhl1963@sina.com
基金资助:
国家863计划资助项目（2012AA022604）；国家自然科学基金（21405015,21275028）；福建省自然科学基金资助项目（2014J05092）；福建省教育厅项目（JA13147）；大学生创新创业训练计划项目基金（201410392030）

Fabrication of Riboflavin Electrochemical Sensor Based on Au Nanoparticles/Polydopamine/Carbon Nanotubes Modified Glassy Carbon Electrode

PENG Hua-ping^1,2, YU Mei-ling¹, LIU Xin¹, LIU Pan^1,2, CHEN Wei^1,2, LIU Ai-lin^1,2, LIN Xin-hua^1,2*

1. Department of Pharmaceutical Analysis of the Fujian Medical University，Fuzhou 350004，China；2. The higher educational key laboratory for Nano Biomedical Technology of Fujian Province, Fujian Medical Univeristy，Fuzhou 350004，China

Received:2015-07-27 Revised:2015-09-03 Published:2016-02-29 Online:2015-09-06
Contact: LIN Xin-Hua E-mail:xhl1963@sina.com

摘要/Abstract

摘要：

采用原位还原法制备金纳米粒子/聚多巴胺/碳纳米管（Au-PDA-MWNTs）复合材料，并将其用于建立高灵敏检测核黄素的电化学方法.采用紫外–可见光谱、扫描电镜、x-射线能谱对Au-PDA-MWNTs复合材料进行表征，采用循环伏安法和差示脉冲伏安法探讨核黄素（RF）在Au-PDA-MWNTs修饰的玻碳电极上的电化学行为，并对RF含量进行测定.该方法对核黄素的检测在5×10^-9 mol·L^-1～1×10^-5 mol·L^-1的范围内呈良好的线性关系（R=0.9906），检测限为1.7×10^-9 mol·L^-1.本方法操作简便、抗干扰能力强，方法可行，因此该方法成功实现了维生素药片中RF含量的测定.

关键词: 核黄素, 金纳米粒子, 聚多巴胺, 多壁碳纳米管, 电化学

Abstract:

A novel electrochemical platform for the high sensitivity detection of riboflavin was constructed by Au nanoparticles/polydopamine/carbon nanotubes (Au-PDA-MWCNTs) nanocomposite modified glassy carbon electrode. The Au-PDA-MWCNTs nanocomposite was synthesized by in situ reduction method. The characteristics of the as-prepared Au-PDA-MWCNTs nanocomposite modified electrodes were investigated by using UV-Vis spectroscopy, scanning electron microscopy (SEM) and electrochemical methods. Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were used to study the electrochemical behavior of riboflavin (RF) at Au-PDA-MWCNTs nanocomposite modified electrodes. The results demonstrated that the present electrochemical sensor exhibited a wide linear range from 5×10^-9 mol•L^-1to 1×10^-5 mol•L^-1 for detection of riboflavin, with a detection limit of 1.7×10^-9 mol•L^-1 (S/N = 3). The present method for high sensitivity determination of riboflavin by electrochemical method at Au-PDA-MWCNTs nanocomposite modified electrodes is simple, accurate, reliable and feasible with an excellent anti-interference ability against electroactive species and metal ions. Accordingly, the present method proved to be useful for the estimation of the RF content in pharmaceutical samples with satisfactory recovery.

Key words: riboflavin, gold nanoparticles, polydopamine, multi-walled carbon nanotubes, electrochemistry

中图分类号:

O657.1

彭花萍, 余美玲, 刘馨, 刘盼, 陈伟, 刘爱林, 林新华*. 金纳米粒子/聚多巴胺/碳纳米管修饰玻碳电极对核黄素的测定[J]. 电化学（中英文）, 2016, 22(1): 43-48.

PENG Hua-ping, YU Mei-ling, LIU Xin, LIU Pan, CHEN Wei, LIU Ai-lin, LIN Xin-hua*. Fabrication of Riboflavin Electrochemical Sensor Based on Au Nanoparticles/Polydopamine/Carbon Nanotubes Modified Glassy Carbon Electrode[J]. Journal of Electrochemistry, 2016, 22(1): 43-48.

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金纳米粒子/聚多巴胺/碳纳米管修饰玻碳电极对核黄素的测定

Fabrication of Riboflavin Electrochemical Sensor Based on Au Nanoparticles/Polydopamine/Carbon Nanotubes Modified Glassy Carbon Electrode

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