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电化学（中英文） ›› 2006, Vol. 12 ›› Issue (2): 170-176.  doi: 10.61558/2993-074X.1717

• 研究论文 • 上一篇    下一篇

旋转玻碳电极上二茂铁的电化学阻抗行为及其与DNA的相互作用

陈灿辉;李红;周剑章;林仲华;朱伟;张全新;   

  1. 华南师范大学化学与环境学院,华南师范大学化学与环境学院,厦门大学固体表面物理化学国家重点实验室厦门大学化学系物理化学研究所,厦门大学固体表面物理化学国家重点实验室厦门大学化学系物理化学研究所,广州市疾病预防控制中心毒理科,广州市疾病预防控制中心毒理科 广东广州510006,广东广州510006,福建厦门361005,福建厦门361005,广东广州510080,广东广州510080
  • 收稿日期:2006-05-28 修回日期:2006-05-28 发布日期:2006-05-28 出版日期:2006-05-28

Electrochemical Impedance Spectrum of Ferrocene at a Rotating Disk Glassy Carbon Electrode and Its Interaction with DNA

CHEN Can-hui~   

  1. (1),LI Hong ~(*1),~()ZHOU Jian-zhang~(2),LIN Zhong-hua~(2),ZHU Wei~(3),ZHANG Quan-xin~(3)(1.School of Chemistry and Environment,South China Normal University,Guangzhou 510006,Guangdong,China,2.State Key Laboratory for Physical Chemistry of the Solid Surface,Department of Chemistry,Institute of Physical Chemistry,Xiamen University,Xiamen 361005,Fujian,China,3.Unit of Molecular Toxicology,Center for Disease Control and Prevention,Guangzhou 510080,Guangdong,China
  • Received:2006-05-28 Revised:2006-05-28 Online:2006-05-28 Published:2006-05-28

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摘要： 应用旋转圆盘电极和电化学阻抗法研究了二茂铁在Tris-NaC l(pH=7.2)缓冲溶液中于旋转玻碳电极上的电化学阻抗行为及其与DNA的相互作用.结果表明,二茂铁于旋转电极的伏安曲线呈现明显的极限电流平阶,而其交流阻抗谱则出现两个电容弧.二茂铁与DNA的作用,若受扩散过程控制则其极限扩散电流随DNA浓度增大而减小,而在电化学控制过程中则表现为电化学反应电阻随DNA浓度增大而增大.根据旋转圆盘电极和电化学阻抗谱测试,表明由这两种方法数据拟合求得的二茂铁条件电位速率常数能够很好地相互吻合,但如存在DNA时,则其条件电位速率常数有一定程度的减小.

关键词: 二茂铁, DNA, 旋转圆盘电极, 电化学阻抗谱

Abstract: The electrochemical impedance spectrum(EIS) of ferrocene(Fc) at a rotating glassy carbon(GC) electrode and its interaction with calf thymus DNA in Tris-NaCl buffer solution(pH=7.2) have been investigated by using electrochemical techniques such as rotating disk electrode(RDE),EIS and its data fitting.A plateau of the limiting current for the voltammetric curve and two capacitance arches obtained at the rotating GC electrode are exhibited.The interaction of Fc with DNA is represented by the decrease of limiting diffusion current and the increase of electrochemical reaction resistances with the increase of DNA concentration,respectively.On the other hand,based on the theoretical analysis and data fitting of RDE and EIS,values of the rate constant at the formal potential obtained by RDE are consistent with those by EIS on the rotating GC electrode.At the same time,the rate constant at the formal potential decreases in the presence of DNA.

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