对乙酰氨基酚在活化玻碳电极上的电化学行为及测定

doi:10.61558/2993-074X.1939

电化学（中英文） ›› 2008, Vol. 14 ›› Issue (4): 441-445. doi: 10.61558/2993-074X.1939

对乙酰氨基酚在活化玻碳电极上的电化学行为及测定

谭宝玉;廖钫;何晓英;朱清涛;华俊;蒋晓丽;

西华师范大学化学化工学院;

收稿日期:2008-11-28 修回日期:2008-11-28 出版日期:2008-11-28 发布日期:2008-11-28

Electrochemical Behavior and Determination of Paracetamol on Activated Glassy Carbon Electrode

TAN Bao-yu,LIAO Fang,HE Xiao-Ying*,ZHU Qing-tao,HUA Jun,JIANG Xiao-li

(Institute of Chemical Engineering,China West Normal University,Nanchong 637002,Sichuan,China

Received:2008-11-28 Revised:2008-11-28 Published:2008-11-28 Online:2008-11-28

摘要/Abstract

摘要： 应用循环伏安法,研究了对乙酰氨基酚(PCT)在活化玻碳电极上的电化学行为.在pH=4.00的HAc-NaAc缓冲溶液中,PCT的CV扫描于0.54 V左右出现一对明显的氧化-还原峰.电极反应为2电子、2质子的受吸附控制的准可逆过程.其氧化峰电流与PCT浓度在8.00×10-6~2.00×10-4mol.L-1范围内呈良好的线性关系,相关系数r=-0.99918;检出限为6.34×10-6mol.L-1.用于药物样品PCT的含量测定,结果满意.

关键词: 对乙酰氨基酚, 活化, 玻碳电极, 循环伏安

Abstract: The electrochemical behavior of paracetamol(PCT) was studied at glassy carbon electrode activated by cyclic voltammetry.In HAc-NaAc buffer solution(pH=4.00),a couple of sensitive redox peaks were recorded about 0.54 V in the cyclic voltammograms.The result indicated that the process was controlled by adsorption and nearly reversible.The reaction electron and proton numbers were estimated,respectively,to be two.Excllent linearity was observed in the correlation between the oxidation peak current and the concentration of PCT in the range of 8.00×10-6～2.00×10-4 mol·L-1.The correlative coefficient was-0.999 18.The detection limit was 6.34×10-6 mol·L-1.This method can be used for the determination of PCT real samples.

Key words: paracetamol, activation, glassy carbon electrode, cyclic voltammetry

中图分类号:

R927

谭宝玉, 廖钫, 何晓英, 朱清涛, 华俊, 蒋晓丽, . 对乙酰氨基酚在活化玻碳电极上的电化学行为及测定[J]. 电化学（中英文）, 2008, 14(4): 441-445.

TAN Bao-yu, LIAO Fang, HE Xiao-Ying, ZHU Qing-tao, HUA Jun, JIANG Xiao-li. Electrochemical Behavior and Determination of Paracetamol on Activated Glassy Carbon Electrode[J]. Journal of Electrochemistry, 2008, 14(4): 441-445.

导出引用管理器 EndNote|Ris|BibTeX

链接本文: https://electrochem.xmu.edu.cn/CN/10.61558/2993-074X.1939

https://electrochem.xmu.edu.cn/CN/Y2008/V14/I4/441

参考文献

[1]Chen xin-qian(陈新谦),Jin you-xiang(金有像).New compilatory pharmaceutics[M].Beijing:People'sMedical Publishing House,2000.154. [2]Espinosa Bosch M,Ruiz S'anchez A J,S'anchez RojasF,et a1.Determination of paracetamol:Historical evo-lution[J].J Pharm Biomed Anal,2006,42(4):291-321. [3]Burgot G,Aufret F,Burgot J L.Determination of ac-ctaminophen by thermometric titrimetry[J].Anal ChimActa,1997,343(1~2):125-128. [4]Hisham E Abdellatef,Magda M Ayad,Suzan M Soli-man,et a1.Spectrophotometric and spectrodensitomet-ric determination of paracetamol and drotaverine HCl incombination[J].Spec Chim Acta Part A,2007,66(4~5):1147-1151. [5]Matin A,Barbas C.CE versus HPLC for the dissolutiontest in a pharmaceutical formulation containing acet-aminophen phenylephrine and chlorpheniramine[J].JPharm Biomed Anal,2004,35:769-777. [6]Zhao Shulin,Bai Wenling,Yuan Hongyan,et a1.De-tection of paracetamol by capillary electrophoresis withchemiluminescence detection[J].Anal Chem Acta,2006,559(2):195-199. [7]Rajendra N Goyal,Vinod K Gupta,Munetaka Oyama,et a1.Differential pulse vohammetric determination ofparacetamol at nano-gold modified indium tin oxide e-lectrode[J].Electrochem Commun,2005,7(8):803-807. [8]Levent zcan,Y櫣celSahin.Determination of paraceta-mol based on electropolymerized-molecularly imprintedpolypyrrole modified pencil graphite electrode[J].SensActuators B:Chem,2007,127(2):362-369. [9]Maria-Elisa Capella-Peir幃,Devasish Bose,Manuel FontRubert,et a1.Optimization of a capillary zone electro-phoresis method by using a central composite factorialdesign for the determination of codeine and paracetamolin pharmaceuticals[J].J Chromatogr B,2006,839(1~2):95-101. [10]Rajendra N Goyal,Sudhanshu P Singh.Vohammetricdetermination of parace-tamol at C60-modified glassycarbon electrode[J].Electrochimica Acta,2006,51(15):3008-30l2. [11]Artur P Terzyk,Gerhard Rychlicki,Stanislaw Biniak,et a1.New correlations between the composition of thesuface layer of cabon and its physicochemical proper-ties exposed while paracetamol is adsorbed at differenttemperatures and pH[J].J Colloid Interface Sci,2003,257(1):13-30. [12]Kang Xin-huang(康信煌),Yang Lin(杨琳),MaiZhi-bin(麦智彬),et al.Electrocatalytic direct deter-mination of paracetamol by square wave voltammetry atnation-soluilized multi-wall carbon nanotubes modifiedglassy carbon electrodes[J].Acta Scientiarum Natu-ralium Universitatis Sunyatseni,2007,46(4):55-58. [13]Zheng Yan-jie(郑艳洁),Chen Jing-hua(陈敬华),Zhang Ya-fen(张亚峰),et al.Electrochemical be-havior and determination of paracetamol at multi-wallnano-carbon tube modified glassy carbon electrode[J].Chin J Pharm Anal,2007,27(2):204-207. [14]Luo Hong-bin(罗红斌),Zhang Ya-feng(张亚锋),Chen Wei(陈伟),et al.Voltammetric behavior andits determination of acetaminophen at poly(congo red)modified electrode[J].Electrochemistry,2006,12(3):329-332. [15]Wang Zheng-guo(王正国).Voltammetric determina-tion of aacetaminophen based on a poly-L-serine modi-fied glassy carbon electrode[J].Chemical Researchand Application,2006,18(9):1095-1098. [16]WangZhen-hui(汪振辉),ZhangYong-hua(张永花),Zhou Shu-ping(周漱萍).Electrochemical be-havior of acetaminophen at poly(acridine orange)modi-fied electrode and its determination by voltammetry[J].Acta Pharmaceutica Sinica,2001,36(11):840-843. [17]Bi Shu-yun(毕淑云),Wang Gui-fen(王桂芬),PiaoYuan-zhe(朴元哲),et a1.Voltammetric determina-tion of paracetamol on the glassy carben electrode[J].Jourhal of Yanbian University(Natural Science Edi-tion),2000,26(2):110-112. [18]Jia zheng(贾铮),Dai chang-song(戴长松),Chenling(陈玲).Measurement methods of electrochemistry[M].Beijing:Chemistry Industry Press,2006.139.

对乙酰氨基酚在活化玻碳电极上的电化学行为及测定

Electrochemical Behavior and Determination of Paracetamol on Activated Glassy Carbon Electrode

PDF (PC)

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

Metrics

[1]	王昊, 曹晓舟, 薛向欣. 锑在氯化胆碱-乙二醇低共熔溶剂中的电沉积研究[J]. 电化学（中英文）, 2022, 28(4): 2103071-.
[2]	蔡雪凡, 孙升. 多孔电极电池的循环伏安法模拟[J]. 电化学（中英文）, 2021, 27(6): 646-657.
[3]	程蕾, 闫普选, 樊友军, 邹华红, 梁宏. 玻碳电极界面的阻抗谱数学表达及定量分析[J]. 电化学（中英文）, 2021, 27(5): 518-528.
[4]	邢逸飞, 李娜, 温晓芳, 韩宏彦, 崔敏, 张聪, 任聚杰, 籍雪平. 基于取代型多酸复合材料的多巴胺电化学检测[J]. 电化学（中英文）, 2020, 26(6): 890-899.
[5]	娄景媛, 尤东江, 李雪菁. 全钒氧化还原液流电池用石墨毡电极的分步氧化活化[J]. 电化学（中英文）, 2020, 26(6): 876-884.
[6]	韩平, 冯海涛, 董亚萍, 田森, 张波, 李武. 氢氧化钠水溶液体系中金属铬的电化学氧化过程[J]. 电化学（中英文）, 2020, 26(3): 413-421.
[7]	郭佳瑶, 陈煅, 张杰, 詹东平. 法拉第吸脱附偶联过程循环伏安行为的有限元分析[J]. 电化学（中英文）, 2020, 26(2): 281-288.
[8]	李明雪, 史杭, 刘佳, 张檬, 周剑章, 吴德印, 田中群. 金电极上偶氮腺嘌呤的电化学行为研究[J]. 电化学（中英文）, 2019, 25(6): 651-659.
[9]	凌云, 汤儆, 刘国坤, 宗铖. 暂态电化学表面增强拉曼光谱研究对硝基苯硫酚分子的电化学还原过程[J]. 电化学（中英文）, 2019, 25(6): 731-739.
[10]	胡锋, 罗丽容, 李永治, 翟亭亭, 赵鑫, 张羊换. 铸态及快淬态CeMg₁₀Ni₂合金电化学储氢热力学及动力学性能研究[J]. 电化学（中英文）, 2019, 25(5): 631-638.
[11]	陈禾木，邱晨曦，丛媛媛，刘会园，翟梓会，宋玉江. 酸处理的碳作为阳极电催化剂用于直接抗坏血酸碱性膜燃料电池[J]. 电化学（中英文）, 2018, 24(6): 748-756.
[12]	M. Rostom Ali, S Sankar Saha, Md Ziaur Rahman. 共晶基离子液体的钴电化学沉积[J]. 电化学（中英文）, 2018, 24(5): 546-554.
[13]	董鹏飞，李娜，赵海燕，崔敏，张聪，任聚杰，藉雪平. Keggin 型磷钨酸盐修饰碳糊电极传感多巴胺的研究[J]. 电化学（中英文）, 2018, 24(5): 555-562.
[14]	黄帅帅，刘诚，金磊，杨防祖，田中群，周绍民. 玻碳电极表面复合配位银电结晶机理研究[J]. 电化学（中英文）, 2018, 24(4): 344-350.
[15]	秦建新，林峰，刘文平，陈超，任孟德. 酸性溶液中Fe²⁺ /Fe³⁺相互转换对电极还原行为的影响[J]. 电化学（中英文）, 2017, 23(6): 702-707.