电化学（中英文） ›› 2022, Vol. 28 ›› Issue (3): 2108551. doi: 10.13208/j.electrochem.210855
所属专题： “电分析”专题文章
徐聪1,3, 江迎2, 于萍1,3, 毛兰群2,*(
)
收稿日期:2021-12-14
修回日期:2022-01-04
出版日期:2022-03-28
发布日期:2022-01-10
Cong Xu1,3, Ying Jiang2, Ping Yu1,3, Lan-Qun Mao2,*()
Received:2021-12-14
Revised:2022-01-04
Published:2022-03-28
Online:2022-01-10
Contact:
*Tel: (86-10)62646525, E-mail:lqmao@bnu.edu.cn
摘要：
大脑是认知、情感等神经活动的物质基础。脑内神经元通过化学信号及电信号相互连接,共同构成动态而复杂的神经信号网络,实现各项神经活动。因此,对于脑神经化学分子的分析与检测有助于揭示神经生理、病理过程中的分子机制,进而发展神经系统疾病的精准诊断及治疗手段。随着各学科的融合与发展,已有多种分析技术在不同层次实现神经分子的检测。其中,电化学分析方法具有高灵敏、高时空分辨等优势,有望在活体层次上精准描述特定神经分子在神经生理或病理过程中的动态变化。本文围绕选择性以及生理兼容性两大关键问题展开,以本课题组最新研究进展为例,系统阐述了电极界面的构筑原则以及电位型检测方法的独特优势,着重介绍了抗坏血酸在神经生理和病理过程中的动态变化规律,并对脑神经电化学分析领域的发展前景进行了展望。
徐聪, 江迎, 于萍, 毛兰群. 脑神经电化学研究[J]. 电化学（中英文）, 2022, 28(3): 2108551.
Cong Xu, Ying Jiang, Ping Yu, Lan-Qun Mao. Brain Electrochemistry[J]. Journal of Electrochemistry, 2022, 28(3): 2108551.
Figure 1
(A) Schematic illustration of mediated electron transfer pathways catalyzed by Fd-Glts[43]. Reproduced with permission of Ref. 43, copyright 2018 American Chemical Society. (B) Schematic illustration of aptCFE and typical current response of in vivo DA dynamics upon electrical stimulation[46]. Reproduced with permission of Ref. 46, copyright 2020 WILEY-VCH. (color on line)
Figure 2
(A) (a-b) HAADF-STEM image (a) and EXAFS fitting curve (b) of Co-N4/C. (c) Relative current ratio of H2O2 to O2 recorded by three catalysts shown in the figure, and (d) in vivo O2 fluctuation recorded by Co-N4/C-based sensor[60]. Reproduced with permission of Ref. 60, copyright 2020 American Chemical Society. (B) (a-b) Schematic illustration of fabrication process (a) and stretching process (b) of Ni SAC/N-C-based sensor. (c) Real-time monitoring of NO release[61]. Reproduced with permission of Ref. 61, copyright 2020 Springer Nature. (C) (a) Schematic illustration of online electrochemical system (OECS) with a SAC-based electrochemical sensor for continuous glucose monitoring, and (b) typical amperometric response of OECS toward microdialysate in vivo sampled from rat brain[62]. Reproduced with permission of Ref. 62, copyright 2019 Springer. (color on line)
Figure 3
(A) Schematic illustration of Pd/GDY formation via electroless deposition[64]. Reproduced with permission of Ref. 64, copyright 2015 American Chemical Society. (B) TEM image (a), HRTEM image (b), STEM image (c), FFT pattern (d) and AFM images (e-f) of exfoliated GDY[65]. Reproduced with permission of Ref. 65, copyright 2019 WILEY-VCH. (C) (a) Schematic illustration of bonding model between water molecules and carbon nanomaterials (i.e., GO and GDYO). (b) Normalized current responses of GDYO-based sensor towards different human respiratory patterns[66]. Reproduced with permission of Ref. 66, copyright 2018 WILEY-VCH. (D) (a) Construction of the mediated biosensor interface and (b) typical amperometric responses to glucose and other neurochemicals[67]. Reproduced with permission of Ref. 67, copyright 2020 American Chemical Society. (color on line)
Figure 4
(A) (a) Typical current-voltage responses acquired by using bare micropipette (black curve) and PimB-modified micro-pipette (red curve). (b) Schematic illustration of proposed three-layer model[69]. Reproduced with permission of Ref. 69, copyright 2017 American Chemical Society. (B) Schematic illustrations of (a) experimental setup of in vivo pH sensing by using PvimB-modified micropipette and (b) transient ion transport behaviors and generated ion currents under high-frequency pulse potential[72]. Reproduced with permission of Ref. 72, copyright 2021 Royal Society of Chemistry. (color on line)
Figure 5
(A) Schematic illustration of GRP sensor[80]. (B) Schematic illustration of orientation and cyclic voltammograms of untreated and ethanol-treated laccase on SWCNT/GCE[79]. Reproduced with permission of Ref. 79, copyright 2017 American Chemical Society. (C) (a) Schematic illustration of GRP sensor for in vivo sensing of AA. (b) Calibration curves of the GRP sensor before and after BSA absorption. (c) Real-time recording of cortical AA level during global cerebral ischemia (red arrow) and reperfusion (blue arrow)[80]. Reproduced with permission of Ref. 80, copyright 2018 American Chemical Society. (D) (a) Schematic illustration of the single-carbon-fiber-powered microsensor and in vivo sensing of AA with the microsensor. (b) Change in open circuit voltage (OCV) after adding AA and interferents. (c) In vivo synchronous OCV measurement with the microsensor and electrophysiological recording by the MEA[81]. Reproduced with permission of Ref. 81, copyright 2020 WILEY-VCH. (color on line)
Figure 6
(A) (a) Current signals recorded with CFEAA1.0 under different bias voltages and (b) in vivo sensing of AA in the rat cortex during SD process[84]. Reproduced with permission of Ref. 84, copyright 2019 WILEY-VCH. (B) Schematic illustration and typical current responses of in vivo AA release in rat brain by using CFEAA2.0[85]. Reproduced with permission of Ref. 85, copyright 2020 American Chemical Society. (color on line)
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