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电化学(中英文) ›› 2011, Vol. 17 ›› Issue (4): 433-437.  doi: 10.61558/2993-074X.2867

• 研究论文 • 上一篇    下一篇

β-环糊精与阿霉素表面包络作用的电化学研究

石健, 张其平, 王南平*   

  1. 南通大学化学化工学院,南通 226007
  • 收稿日期:2011-07-08 修回日期:2011-08-01 出版日期:2011-11-28 发布日期:2011-09-29
  • 通讯作者: 王南平 E-mail:bobow56@163.com

Electrochemical Studies on Surface Inclusion of β-Cyclodextrin with Adriamycin

SHI Jian, ZHANG Qi-Ping, WANG Nan-Ping*   

  1. School of Chemistry and Chemical Engineering, Nantong University, Nantong 226007, Jiangsu China
  • Received:2011-07-08 Revised:2011-08-01 Published:2011-11-28 Online:2011-09-29
  • Contact: WANG Nan-Ping E-mail:bobow56@163.com

摘要: 研究了阿霉素(ADM)在β-环糊精(β-CD)修饰金电极上的电化学行为,结果表明,β-CD/Au电极ADM发生表面包络反应。25 ℃,pH=7.0时,该电极表面包络常数为9.54×104 L?mol-1,表面包络常数随温度呈规律性变化,最适宜反应温度为30℃。该电极ADM包络呈准可逆的电化学反应,其速率常数为0.0995 s-1。在20~40 μmol?L-1浓度范围β-CD/Au电极ADM的还原峰电流与浓度呈线性关系,线性方程 Ip=2.024+0.0057C,相关系数0.9911,检出限6.5 μmol?L-1。

关键词: 阿霉素, β-环糊精, 修饰电极, 包络

Abstract: The β-cyclodextrin (β-CD) modified gold electrode (β-CD/Au) was fabricated to study the electrochemical behavior of adriamycin (ADM). The results indicated that the complexing reaction of ADM with β-CD took place at the β-CD/Au surface. At 25 ℃,the complexing constant (K) was 9.54×104 L?mol-1 in pH=7.0. The K values changed regularly with temperature, and the most suitable temperature of the surface inclusion reaction was 30 ℃. The complexing reaction of ADM with β-CD at the β-CD/Au surface could undergo the quasi-reversible electrochemical reaction with the rate constant being 0.0995 s-1. The cathodic peak current (Ip) of ADM was proportional to the concentration of ADM in the 20~40 μmol?L-1. The linear regression equation for the quantitative determination of ADM concentration (C) by β-CD/Au was Ip=2.024+0.0057C with a correlation coefficient of 0.9911. The detection limit was 6.5 μmol?L-1.

Key words: adriamycin, β-cyclodextrin, modified electrode, complex

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