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研究论文

β-环糊精与阿霉素表面包络作用的电化学研究

  • 石健 ,
  • 张其平 ,
  • 王南平
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  • 南通大学化学化工学院,南通 226007

收稿日期: 2011-07-08

  修回日期: 2011-08-01

  网络出版日期: 2011-09-29

Electrochemical Studies on Surface Inclusion of β-Cyclodextrin with Adriamycin

  • SHI Jian ,
  • ZHANG Qi-Ping ,
  • WANG 南Ping
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  • School of Chemistry and Chemical Engineering, Nantong University, Nantong 226007, Jiangsu China

Received date: 2011-07-08

  Revised date: 2011-08-01

  Online published: 2011-09-29

摘要

研究了阿霉素(ADM)在β-环糊精(β-CD)修饰金电极上的电化学行为,结果表明,β-CD/Au电极ADM发生表面包络反应。25 ℃,pH=7.0时,该电极表面包络常数为9.54×104 L?mol-1,表面包络常数随温度呈规律性变化,最适宜反应温度为30℃。该电极ADM包络呈准可逆的电化学反应,其速率常数为0.0995 s-1。在20~40 μmol?L-1浓度范围β-CD/Au电极ADM的还原峰电流与浓度呈线性关系,线性方程 Ip=2.024+0.0057C,相关系数0.9911,检出限6.5 μmol?L-1。

本文引用格式

石健 , 张其平 , 王南平 . β-环糊精与阿霉素表面包络作用的电化学研究[J]. 电化学, 2011 , 17(4) : 433 -437 . DOI: 10.61558/2993-074X.2867

Abstract

The β-cyclodextrin (β-CD) modified gold electrode (β-CD/Au) was fabricated to study the electrochemical behavior of adriamycin (ADM). The results indicated that the complexing reaction of ADM with β-CD took place at the β-CD/Au surface. At 25 ℃,the complexing constant (K) was 9.54×104 L?mol-1 in pH=7.0. The K values changed regularly with temperature, and the most suitable temperature of the surface inclusion reaction was 30 ℃. The complexing reaction of ADM with β-CD at the β-CD/Au surface could undergo the quasi-reversible electrochemical reaction with the rate constant being 0.0995 s-1. The cathodic peak current (Ip) of ADM was proportional to the concentration of ADM in the 20~40 μmol?L-1. The linear regression equation for the quantitative determination of ADM concentration (C) by β-CD/Au was Ip=2.024+0.0057C with a correlation coefficient of 0.9911. The detection limit was 6.5 μmol?L-1.
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