金超微电极原位电沉积FeCo-MOF电化学检测肾上腺素

doi:10.61558/2993-074X.3516

电化学（中英文） ›› 2025, Vol. 31 ›› Issue (3): 2417001. doi: 10.61558/2993-074X.3516

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金超微电极原位电沉积FeCo-MOF电化学检测肾上腺素

陈妍^a^,^b^,^#, 商建^c^,^#, 万思宇^a^,^b, 崔晓彤^a^,^b, 刘中刚^a^,^b^,^*(), 郭正^a^,^b^,^*()

^a信息材料与智能感知安徽省实验室，安徽大学物质科学与信息技术研究院，安徽合肥，230601
^b杂化材料结构与功能调控教育部重点实验室，安徽大学，安徽合肥，230601
^c中化国际新材料（河北）有限公司技术分公司，河北石家庄，050000

收稿日期:2024-10-21 修回日期:2024-11-25 接受日期:2024-12-06 出版日期:2025-03-28 发布日期:2024-12-31

In-situ Electrodeposition of FeCo-MOF on Au Ultramicroelectrode for Highly Sensitive Detection of Epinephrine

Yan Chen^a^,^b^,^#, Jian Shang^c^,^#, Si-Yu Wan^a^,^b, Xiao-Tong Cui^a^,^b, Zhong-Gang Liu^a^,^b^,^*(), Zheng Guo^a^,^b^,^*()

^aInformation Materials and Intelligent Sensing Laboratory of Anhui Province, Institutes of Physical Science and Information Technology, Anhui University, Hefei, 230601, P.R. China
^bKey Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Anhui University, Hefei, 230601, P.R. China
^cSINOCHEM International Advanced Materials (Hebei) CO., LTD. Technology Branch, Shijiazhuang, 050000, P.R. China

Received:2024-10-21 Revised:2024-11-25 Accepted:2024-12-06 Published:2025-03-28 Online:2024-12-31
Contact: *E-mail: zhgliu@ahu.du.cn; E-mail: zhguo@ahu.edu.cn
About author:^#These authors contributed equally to this work.

1. 附件.pdf(804KB)

摘要/Abstract

摘要：

金属-有机框架（MOF）纳米材料因其独特性质显著促进了电化学传感器的发展。合理设计双金属MOF并集成与微电极对于提高电化学性能至关重要，但仍然面临巨大挑战。本工作中通过原位电沉积方法将双金属FeCo-MOF纳米材料组装于金超微电极（Au UME，直径约为5.2 µm）表面，并应用于肾上腺素（EP）的电化学检测。FeCo-MOF呈现类纳米花结构，均匀分散在超微电极基底上。FeCo-MOF/Au UME在EP检测中表现出较好的电化学性能，具有高灵敏度36.93 μA·μmol^-1·L·cm^-2和低检测限1.28 μmol·L^-1。这可归因于EP在超微电极基底的非线性快速传质特点，以及基于MOF结构中Fe、Co双金属的协同催化效应。此外，我们将FeCo-MOF/Au UME成功应用于人血清样本中EP的检测，且表现出较高回收率。本研究工作不仅有助于扩展电化学传感器研究领域，还将为设计开发基于MOF纳米敏感材料的微纳电化学传感器件提供指导和借鉴。

关键词: FeCo-MOF, 金超微电极, 原位电沉积, 电分析, 肾上腺素

Abstract:

Metal-organic framework (MOF) nanostructures have emerged as a prominent class of materials in the advancement of electrochemical sensors. The rational design of bimetallic MOF-functionalized microelectrode is of importance for improving the electrochemical performance but still in great challenge. In this work, the bimetallic FeCo-MOF nanostructures were assembled onto a gold disk ultramicroelectrode (Au UME, 5.2 µm in diameter) via an in-situ electrodeposition method, which enhanced the sensitive detection of epinephrine (EP). The in-situ electrodeposited FeCo-MOF exhibited a characteristic nanoflower-like morphology and was uniformly dispersed on the Au UME. The FeCo-MOF/Au UME demonstrated excellent electrochemical performance on the detection of EP with a high sensitivity of 36.93 μA·μmol^-1·L·cm^-2 and a low detection limit of 1.28 μmol·L^-1. It can be attributed to the nonlinear diffusion of EP onto the ultra-micro working substrate, coupled with synergistical catalytic activity of the bimetallic Fe, Co within MOF structure. Furthermore, the FeCo-MOF/Au UME has been successful applied to the analysis of EP in human serum samples, yielding high recovery rates. These results not only contribute to the expansion of the research area of electrochemical sensors, but also provide novel insights and directions into the development of high-performance MOF-based electrochemical sensors.

Key words: FeCo-MOF, gold disk ultramicroelectrode, in-situ electrodeposition, electroanalysis, epinephrine

陈妍, 商建, 万思宇, 崔晓彤, 刘中刚, 郭正. 金超微电极原位电沉积FeCo-MOF电化学检测肾上腺素[J]. 电化学（中英文）, 2025, 31(3): 2417001.

Yan Chen, Jian Shang, Si-Yu Wan, Xiao-Tong Cui, Zhong-Gang Liu, Zheng Guo. In-situ Electrodeposition of FeCo-MOF on Au Ultramicroelectrode for Highly Sensitive Detection of Epinephrine[J]. Journal of Electrochemistry, 2025, 31(3): 2417001.

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链接本文: https://electrochem.xmu.edu.cn/CN/10.61558/2993-074X.3516

https://electrochem.xmu.edu.cn/CN/Y2025/V31/I3/2417001

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Sample	Added (µmol·L^-1)	Found (µmol·L^-1)	Recovery (%)	RSD (%)
S1	20 50	19.38 ± 1.03 53.2 ± 1.16	96.94 106.4	5.33 2.18
S2	20 50	19.46 ± 0.84 48.69 ± 0.71	102.5 97.38	4.18 1.46
S3	20 50	20.47 ± 1.33 48.52 ± 1.44	102.05 97.04	6.48 2.98
S4	20 50	20.93 ± 0.37 49.95 ± 2.89	104.65 99.91	1.77 5.78
S5	20 50	19.94 ± 0.39 51.02 ± 1.24	99.68 102.02	1.93 2.43
S6	20 50	20.57 ± 0.23 52.43 ± 1.15	102.85 103.33	1.12 2.19

金超微电极原位电沉积FeCo-MOF电化学检测肾上腺素

In-situ Electrodeposition of FeCo-MOF on Au Ultramicroelectrode for Highly Sensitive Detection of Epinephrine

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