The microbial infection of biomaterials often causes clinic problems and sometimes even leads to the prosthesis failure. It is, therefore, important to prevent the biomaterials from bacterial contamination. This can be done by using anti-bacteria drugs. However, this method causes physiological burdens to the patients and does not always work. To stop the contamination from the just beginning is believed to be a better choice. The first step for infection is the attachment of bacteria on the material. In this work, the thin TiO2 nanotubes array films were constructed with totally different wettabilities showing either superhydrophobic or superhydrophilic. The bacterial attachment behaviors on them were evaluated. It is shown that the numbers of viable colonies on the superhydrophobic film were significantly less than those on the superhydrophilic one.
1. M.K.C. Lawson, C.N. Bowman, K.S. Anseth, Vancomycin derivative photopolymerized to titanium kills S. epidermidis [J], Clinical orthopaedics and related research, 2007, 461: 96.
2. R.A. Hartvig, M. van de Weert, J. stergaard, L. Jorgensen, H. Jensen, Protein Adsorption at Charged Surfaces: The Role of Electrostatic Interactions and Interfacial Charge Regulation [J], Langmuir, 2011.
3. C. Price, M. Waters, D. Williams, M. Lewis, D. Stickler, Surface modification of an experimental silicone rubber aimed at reducing initial candidal adhesion [J], Journal of biomedical materials research, 2002, 63: 122-128.
4. E.P.J.M. Everaert, H.C. van der Mei, H.J. Busscher, Adhesion of yeasts and bacteria to fluoro-alkylsiloxane layers chemisorbed on silicone rubber [J], Colloids and Surfaces B: Biointerfaces, 1998, 10: 179-190.
5. H. Tang, T. Cao, A. Wang, X. Liang, S.O. Salley, I. McAllister, P. James, K. Ng, Effect of surface modification of siliconeon Staphylococcus epidermidis adhesion and colonization [J], Journal of Biomedical Materials Research Part A, 2007, 80: 885-894.
6. T. Cao, H. Tang, X. Liang, A. Wang, G.W. Auner, S.O. Salley, K. Ng, Nanoscale investigation on adhesion of E. coli to surface modified silicone using atomic force microscopy [J], Biotechnology and bioengineering, 2006, 94: 167-176.
7. M. Raulio, M. J rn, J. Ahola, J. Peltonen, J.B. Rosenholm, S. Tervakangas, J. Kolehmainen, T. Ruokolainen, P. Narko, M. Salkinoja-Salonen, Microbe repelling coated stainless steel analysed by field emission scanning electron microscopy and physicochemical methods [J], Journal of Industrial Microbiology and Biotechnology, 2008, 35: 751-760.
8. G. Lerebour, S. Cupferman, M. Bellon-Fontaine, Adhesion of Staphylococcus aureus and Staphylococcus epidermidis to the Episkin(R) reconstructed epidermis model and to an inert 304 stainless steel substrate [J], Journal of applied microbiology, 2004, 97: 7-16.
9. A. Okada, T. Nikaido, M. Ikeda, K. Okada, J. Yamauchi, R.M. Foxton, H. Sawada, J. Tagami, K. Matin, Inhibition of biofilm formation using newly developed coating materials with self-cleaning properties [J], Dental materials journal, 2008, 27: 565-572.
10. X. Song, J. Zhai, Y. Wang, L. Jiang, Fabrication of superhydrophobic surfaces by self-assembly and their water-adhesion properties [J], The Journal of Physical Chemistry B, 2005, 109: 4048-4052.
11. Y. Lai, C. Lin, J. Huang, H. Zhuang, L. Sun, T. Nguyen, Markedly controllable adhesion of superhydrophobic spongelike nanostructure TiO2 films [J], Langmuir, 2008, 24: 3867-3873.
12. Y. Wu, F.I. Simonovsky, B.D. Ratner, T.A. Horbett, The role of adsorbed fibrinogen in platelet adhesion to polyurethane surfaces: A comparison of surface hydrophobicity, protein adsorption, monoclonal antibody binding, and platelet adhesion [J], Journal of Biomedical Materials Research Part A, 2005, 74: 722-738.
13. D. Hanein, B. Geiger, L. Addadi, Fibronectin adsorption to surfaces of hydrated crystals. An analysis of the importance of bound water in protein-substrate interactions [J], Langmuir, 1993, 9: 1058-1065.
14. U. J nsson, B. Ivarsson, I. Lundstr m, L. Berghem, Adsorption behavior of fibronectin on well-characterized silica surfaces [J], Journal of Colloid and Interface Science, 1982, 90: 148-163.
15. D. Absolom, W. Zingg, A. Neumann, Protein adsorption to polymer particles: role of surface properties [J], Journal of biomedical materials research, 1987, 21: 161-171.
16. D. MacDonald, N. Deo, B. Markovic, M. Stranick, P. Somasundaran, Adsorption and dissolution behavior of human plasma fibronectin on thermally and chemically modified titanium dioxide particles [J], Biomaterials, 2002, 23: 1269-1279.
