由于具有可降解性和生物相容性，镁合金被认为是生物植入物应用的有前景的候选材料。然而，其快速腐蚀仍然是一个关键的限制因素。本研究开发了一种多功能纳米复合涂层，旨在提高镁合金植入物的耐腐蚀性和抗菌性能。该涂层由装饰有TiO₂@Ag核-壳纳米颗粒的γ-环糊精金属有机框架（γ-CD MOF）构成，并嵌入在聚己内酯（PCL）基体中。在模拟体液（SBF）中的浸泡测试表明，PCL-TiO₂@Ag/γ-CD MOF涂层在初期的腐蚀速率高于PCL/γ-CD MOF涂层；但随着时间的推移，性能显著改善。五天后，腐蚀抑制率达到95.44%，腐蚀速率降至1.70 mpy。此外，该复合涂层对大肠杆菌（E. coli）、假单胞菌和金黄色葡萄球菌（S. aureus）表现出较强的抗菌活性。MTT测定结果表明，该涂层促进了成骨样MC3T3-E1细胞的生长和增殖，证实其无毒性和良好的生物相容性。这些结果表明，PCL-TiO₂@Ag/γ-CD MOF纳米复合涂层在可降解镁合金植入物中具有良好的生物相容性、抗菌性和耐腐蚀性，展示了其在生物医学应用中的广阔前景。

Magnesium alloys are promising candidates for bio-implant applications due to their biodegradability and biocompatibility. However, their rapid corrosion remains a critical limitation. This study presents the development of a multifunctional nanocomposite coating designed to enhance the corrosion resistance and antibacterial properties of magnesium alloy implants. The coating comprises γ-cyclodextrin metal-organic frameworks (γ-CD MOFs) decorated with TiO₂@Ag core-shell nanoparticles, embedded in a polycaprolactone (PCL) matrix. Immersion tests in simulated body fluid (SBF) revealed an initially higher corrosion rate for the PCL-TiO₂@Ag/γ-CD MOF coating compared to the PCL/γ-CD MOF coating; however, it demonstrated significant improvement over time. After five days, the corrosion inhibition reached 95.44%, with the corrosion rate decreasing to 1.70 mpy. Additionally, the composite coating exhibited strong antibacterial activity against Escherichia coli (E. coli), Pseudomonas, and Staphylococcus aureus (S. aureus). Furthermore, MTT assays indicated that the coating facilitated the growth and proliferation of osteoblast-like MC3T3-E1 cells, confirming its non-toxicity and biocompatibility. These findings highlight the potential of the PCL-TiO₂@Ag/γ-CD MOF nanocomposite as a biocompatible, antibacterial, and corrosion-resistant coating for biodegradable magnesium implants, offering a promising solution for biomedical applications.