金超微电极原位电沉积FeCo-MOF电化学检测肾上腺素
收稿日期: 2024-10-21
修回日期: 2024-11-25
录用日期: 2024-12-06
网络出版日期: 2024-12-31
In-situ Electrodeposition of FeCo-MOF on Au Ultramicroelectrode for Highly Sensitive Detection of Epinephrine
Received date: 2024-10-21
Revised date: 2024-11-25
Accepted date: 2024-12-06
Online published: 2024-12-31
金属-有机框架（MOF）纳米材料因其独特性质显著促进了电化学传感器的发展。合理设计双金属MOF并集成与微电极对于提高电化学性能至关重要，但仍然面临巨大挑战。本工作中通过原位电沉积方法将双金属FeCo-MOF纳米材料组装于金超微电极（Au UME，直径约为5.2 µm）表面，并应用于肾上腺素（EP）的电化学检测。FeCo-MOF呈现类纳米花结构，均匀分散在超微电极基底上。FeCo-MOF/Au UME在EP检测中表现出较好的电化学性能，具有高灵敏度36.93 μA·μmol-1·L·cm-2和低检测限1.28 μmol·L-1。这可归因于EP在超微电极基底的非线性快速传质特点，以及基于MOF结构中Fe、Co双金属的协同催化效应。此外，我们将FeCo-MOF/Au UME成功应用于人血清样本中EP的检测，且表现出较高回收率。本研究工作不仅有助于扩展电化学传感器研究领域，还将为设计开发基于MOF纳米敏感材料的微纳电化学传感器件提供指导和借鉴。
陈妍 , 商建 , 万思宇 , 崔晓彤 , 刘中刚 , 郭正 . 金超微电极原位电沉积FeCo-MOF电化学检测肾上腺素[J]. 电化学, 2025 , 31(3) : 2417001 . DOI: 10.61558/2993-074X.3516
Metal-organic framework (MOF) nanostructures have emerged as a prominent class of materials in the advancement of electrochemical sensors. The rational design of bimetallic MOF-functionalized microelectrode is of importance for improving the electrochemical performance but still in great challenge. In this work, the bimetallic FeCo-MOF nanostructures were assembled onto a gold disk ultramicroelectrode (Au UME, 5.2 µm in diameter) via an in-situ electrodeposition method, which enhanced the sensitive detection of epinephrine (EP). The in-situ electrodeposited FeCo-MOF exhibited a characteristic nanoflower-like morphology and was uniformly dispersed on the Au UME. The FeCo-MOF/Au UME demonstrated excellent electrochemical performance on the detection of EP with a high sensitivity of 36.93 μA·μmol-1·L·cm-2 and a low detection limit of 1.28 μmol·L-1. It can be attributed to the nonlinear diffusion of EP onto the ultra-micro working substrate, coupled with synergistical catalytic activity of the bimetallic Fe, Co within MOF structure. Furthermore, the FeCo-MOF/Au UME has been successful applied to the analysis of EP in human serum samples, yielding high recovery rates. These results not only contribute to the expansion of the research area of electrochemical sensors, but also provide novel insights and directions into the development of high-performance MOF-based electrochemical sensors.
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