基于单细胞尺度的纳米移液管递送研究
收稿日期: 2024-04-29
录用日期: 2024-08-09
网络出版日期: 2024-08-21
Precision Delivery Using Nanopipette for Single-Cell Studies
Received date: 2024-04-29
Accepted date: 2024-08-09
Online published: 2024-08-21
张鹤 , Md Maksudur Rahman , 陶洋 , Joseph W Sampson , 任航 . 基于单细胞尺度的纳米移液管递送研究[J]. 电化学, 2024 , 30(11) : 2414002 . DOI: 10.61558/2993-074X.3488
Nanopipette based scanning probe technique is a versatile tool in non-contact imaging in biology. In addition to the topographic imaging, its capability of localized delivery of bio-active molecules is emerging. In this mini review, we introduce the applications of nanopipette in single-cell researches with a focus on localized delivery. The working principles of three delivery modes including resistive pulse, pressure-driven flow, and electroosmotic flow-driven delivery are summarized and compared. Their applications in single-cell researches are reviewed. The current technical challenges in scanning ion conductance microscopy-based delivery, and their growing influence in medicine and pharmacologic researches are also discussed.
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