硫酸特布他林在聚铬黑T修饰电极上的电化学行为及其测定
收稿日期: 2016-01-07
修回日期: 2016-02-14
网络出版日期: 2016-02-19
基金资助
国家863计划项目（2012AA022604）；国家自然科学基金（81171668，21405015 ）；福建省教育厅科技A类项目（JA13147）；大学生创新创业训练计划项目（201410392034，201510392099）资助.
Electrochemical Behaviors and Determinations of Terbutaline Sulfate at Poly Eriochrome Black T Modified Electrode
Received date: 2016-01-07
Revised date: 2016-02-14
Online published: 2016-02-19
采用电化学聚合法制备了聚铬黑T膜修饰电极，应用扫描电镜、交流阻抗法和循环伏安法对修饰电极进行表征，以循环伏安法研究硫酸特布他林在修饰电极上的电化学行为，并以差示脉冲伏安法对其含量进行测定.该方法对硫酸特布他林有明显的电催化作用，在pH 7.0磷酸盐缓冲液中，氧化峰电流与硫酸特布他林浓度在1.2x10-7~2.0x10-6 mol•L-1范围内呈良好的线性关系，检测限为1.5x10-8 mol•L-1，回收率在97.9%～104.6%之间，RSD在2.8 % (C=8x10-7 mol•L-1，n=11).该方法简便灵敏，结果准确可靠，方法重复性好，可用于硫酸特布他林及其片剂的质量控制.
郑艳洁 , 姚宏 , 翁少煌 , 彭花萍 , 龚仕文 , 黄莉 , 戴强 , 林新华 . 硫酸特布他林在聚铬黑T修饰电极上的电化学行为及其测定[J]. 电化学, 2016 , 22(6) : 617 -623 . DOI: 10.13208/j.electrochem.160107
The poly eriochrome black T modified electrode was prepared by electropolymerization. This modified electrode was characterized by scanning electron microscopy(SEM), electrochemical impedance spectroscopy(EIS) and cyclic voltammetry (CV). The electrochemical behaviors of terbutaline sulfate were studied by CV, while the recoveries were measured by differential pulse voltammetry (DPV). The modified electrode shows excellent electrocatalytic characteristics for terbutaline sulfate. In pH 7.0 phosphate buffer solution, the oxidation peak currents obtained by DPV were linear to the terbutaline sulfate concentrations over the range of 1.2x10-7~2.0x10-6 mol•L-1. The detection limit was estimated to be 1.5x10-8 mol•L-1 and the average recovery was 97.9%～104.6%. The relative standard deviation (RSD) was 2.8% for 8x10-7mol•L-1terbutaline sulfate (n=11). This method is simple, sensitive, and accurate with good repeatability, and can be used for the determination of terbutaline sulfate and the corresponding tablets.
[1] Liu C(刘春), Feng X G(冯新国), Zhang H(张慧). Curative effect of budesonide combined with terbutaline atomization-inhalation in the treatment of acute asthmatic attack in children and its impaction on pulmonary function [J]. Chin J Modern Med(中国当代医药), 2013,20(30) :78-79.
[2] Zhou Z W（周忠卫）.Therapeutic observation of atomization on the treatment of chronic obstructive pulmonary disease on acute exacerbation with budesonide and terbutaline [J]. Pract J of Cardiac Cereb Pneum Vasc Dis(实用心脑肺血管病杂志), 2014,22(11):65-66.
[3] Lin P(林萍), Deng Y(邓扬). Clinical study of atomization on the treatment of chronic obstructive pulmonary disease on acute exacerbation with budesonide and terbutaline[J]. Chin J Prac Med(中国实用医药), 2014,9(4):164-165.
[4] Yan X P(严小平), Fag Y G(方应国), Li C P(李成平), et al. HPLC determination content of terbutaline sulfate tablets [J]. Chin J Pharm Anal (药物分析杂志), 2010,30( 2):217-219.
[5] Chen X L(陈效兰),Yang J(杨娟),Xu S J(徐淑静), et al. Determination of terbutaline sulfate based on the enhancement chemiluminescence of Ag nanoparticles in luminol-potassium ferricyanide chemiluminescence system [J].Chin J Anal Chem(分析化学), 2009,37(11):1662-1666.
[6] Shi A X(史爱欣), Li K X(李可欣),
[7] Deng G H(邓光辉),Chen S Y(陈盛余),Gao J(高静), et al. Separation and determination of clenbuterol hydrochloride，terbutaline and salbutamol by capillary electrophoresis with electrochemical detection [J].Chin J Anal Lab(分析试验室), 2012,31(2):25-27.
[8] Zhang Y Q(张玉琴). Electro activity of the terbutaline on the multi-wall carbon nanotubes modified electrode [J]. J Wuhu Vocational Institute of Tech(芜湖职业技术学院学报), 2007,9(4):5-7.
[9] Wei Y(尉艳), Liu H Y(刘红英),Li M G(李茂国), et al.Electrocatalytic determination of terbutaline using a multi-wall carbon nanotubes coated ceria nanoparticles modified electrode [J].Chin J Anal Lab(分析试验室),2008,27(5):1-4.
[10] Luo S X(罗宿星), Wu Y H(伍远辉),Yang H(杨红), et al. Electrochemical behavior of terbutaline sulfate at graphene modified glassy carbon electrode and its application analysis [J].Surface Tech(表面技术), 2013,42(3):112-115.
[11] Li Y M, Ye Z, Zhou J, et al. A new voltammetric sensor based on poly(L-arginine)/graphene-Nafion composite film modified electrode for sensitive determination of Terbutaline sulfate [J]. J Electroanal Chem, 2012,687(22): 51-57.
[12] Yao H, Sun Y Y, Lin X H, et al. Electrochemical characterization of poly( eriochrome black T) modified glassy carbon electrode and its application to simultaneous determination of dopamine, ascorbic acid and uric acid[J]. Electrochimica Acta, 2007, 52(20): 6165-6171.
[13] The
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