二次微分简易示波伏安法测定酚磺乙胺

电化学（中英文） ›› 2005, Vol. 11 ›› Issue (2): 224-227.

二次微分简易示波伏安法测定酚磺乙胺

倪宏刚,张宏芳,郑建斌

西北大学分析科学研究所,西北大学分析科学研究所,西北大学分析科学研究所陕西省电分析化学重点实验室,陕西西安710069 ,陕西省电分析化学重点实验室,陕西西安710069 ,陕西省电分析化学重点实验室,陕西西安710069

收稿日期:2005-05-28 修回日期:2005-05-28 出版日期:2005-05-28 发布日期:2005-05-28

Oscillographic Determination of Ethamsylate

NI Hong-gang, ZHANG Hong-fang, ZHENG Jian-bin~*

(Institute of Analytical Science, Shanxi Provincial Key Laboratory of Electroanalytical Chemistry, Northwest University, Xi'an 710069, China

Received:2005-05-28 Revised:2005-05-28 Published:2005-05-28 Online:2005-05-28

摘要/Abstract

摘要： 在0.2mol·L-1NaOH底液中,酚磺乙胺的氧化产物能够在示波图阴极支-0.3V处产生一个灵敏的切口,在一定的浓度范围内其二次微分简易示波伏安峰峰高随酚磺乙胺浓度的增大而线性增加,可用于酚磺乙胺片和注射液酚磺乙胺含量的测定.线性范围1.5×10-5～3.4×10-4mol·L-1,回归方程:h(V)=135.6+3.29×106C(mol·L-1),r=0.9921,检出限:6.0×10-6mol·L-1.对3.0×10-5mol·L-1酚磺乙胺5次测定的RSD为2.1%.与高效液相色谱及其他方法相比,本方法具有仪器简单、简便快速、无需通氮除氧等特点.

关键词: 示波分析, 示波测定, 药物分析, 酚磺乙胺

Abstract: In 0.2 mol L~(-1) NaOH solution, ethamsylate can yield a sensitive incision on cathodic branch of dE/dt-E osillogram at 0.3V (vs. SCE). Based on the oscillographic characteristic, a second order differential simple oscillographic voltammetry for determination of ethamsylate in tablet and injection is presented in this paper. The peak height on second order differential simple oscillographic voltammogram is linearly proportional to concentration of the ethamsylate in the range of 1.5×10~(-5)～3.4×10~(-4) mol·L~(-1 )with a 0.9921 correlation coefficient and a detection limit of 6.0×10~(-6 )mol·L~(-1 ) for ethamsylate. The relative standard deviation is 2.1% for the determination of 3.0 10~(-5) mol L~(-1) ethamsylate (n=5). Compared with HPLC and other methods, the second order differential simple oscillographic voltammetry is a convenient method due to its cheap equipment and rapid measurement.

Key words: Oscillographic analysis, Oscillographic determination, Drug analysis, Ethamsylate

中图分类号:

倪宏刚,张宏芳,郑建斌. 二次微分简易示波伏安法测定酚磺乙胺[J]. 电化学（中英文）, 2005, 11(2): 224-227.

NI Hong-gang, ZHANG Hong-fang, ZHENG Jian-bin~*. Oscillographic Determination of Ethamsylate[J]. Journal of Electrochemistry, 2005, 11(2): 224-227.

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